Diagnostic
and Therapeutic Implications of ST-Segment Elevation in Lead aVR of 12 Lead ECG During Chest Pain
Naveed Akhtar, Uzma Bashir, Waqas Ahmed, Syed Mumtaz Ali Shah
Department of
cardiology,
‘aVR’ is usually not the preferred lead to diagnose
myocardial infarction in clinical settings, it is rather a neglected lead in
this context. We describe the case of a 44 year old male who presented with
short duration chest pain and ST segment elevation in lead ‘aVR’. His left
heart catheterization showed left main stem equivalent disease and totally
occluded right coronary artery. Patient underwent emergency coronary artery
bypass-grafting with favorable outcome. This case highlights the significance
of ST segment elevation in lead aVR during chest pain both in diagnosis and
management of patients with acute coronary syndrome.
Keywords: ST segment elevation, aVR, left main stem occlusion.
INTRODUCTION
ECG is a simple, cheap and easily accessible
diagnostic tool for the diagnosis of myocardial ischemia in clinical use since
1920’s. ‘ST’ segment deviation towards the involved myocardium has become the
standard indication of the acute coronary thrombosis of threatened myocardium. ‘aVR’
is an augmented limb lead in which the exploring electrode (positive terminal )
is attached to right arm. It faces the heart from right shoulder. As it is
oriented to the cavity of the heart, both atrial and ventricular vectors are
directed away from it, hence all the deflections including P, QRS and T
deflections are normally negative in this lead.1
So far aVR has had very limited utility in
the diagnosis of myocardial infarction. Lately, studies have provided an
insight to the importance of lead aVR in the resting ECG recorded during chest
pain. A characteristic pattern: ST segment depression in lead I, II and V4-6 and elevation in aVR has been shown to
be of value in identifying high risk patients with three vessel or left main
coronary artery disease.2,3
Further refinement in this criteria has
been made by the finding of lead aVR ST segment elevation greater than or equal
to lead V1, distinguished left main coronary artery group from left
anterior descending group with 81% sensitivity and 80% specificity and 81% accuracy.4
Recently Barrabes et al. have also shown that lead aVR in patients with a first
non-ST segment elevation carries important short term prognostic information.5
We present case of a patient with ST segment elevation in lead aVR highlighting the importance of this electrocardiographic sign in the management of acute coronary syndrome especially in cardiac care setup of Pakistan.
CASE REPORT
A 44 years old male was shifted from a local hospital
to our emergency room with 30 minutes duration of sudden, severe crushing left
sided chest pain radiating to right arm. Risk factors included history of heavy
smoking. In previous hospital he was treated with O2, low molecular
weight heparin, aspirin, beta blockers and nitrates. Upon arrival he was
hemodynamically stable and clinical examination was unremarkable.
He was accompanied by an ECG done at
previous hospital that showed ST segment elevation of 3mm in aVR and 1.5mm in
lead V1, ST segment depressions of 2-4 mm in leads I,II, aVL, aVF, V3-6
(Fig-1).
Keeping in view the ominous nature of ECG
changes that have been found to be a highly specific and sensitive predictor
for left main coronary artery obstruction, the patient was immediately shifted
to cardiac catheterization laboratory. Left heart catheterization showed normal
left main coronary artery. Left anterior descending artery was completely
occluded with collaterals from distal Right Coronary Artery (RCA), left
circumflex artery showed 95% proximal stenosis with 80% Obtuse Marginal (OM) stenosis
(Fig-2). Right coronary artery was dominant with proximal total occlusion.
Distal vessel filled via left circumflex collaterals (Fig-3). Left
ventriculogram showed severe anterolateral and inferior hypokinesia with an
ejection fraction of 25-30%. In summary, the patient had total RCA occlusion
and critical proximal disease in both left anterior descending and circumflex
arteries making it left main stem equivalent disease. Patient underwent
emergency coronary artery bypass-grafting (CABG). Five grafts were placed, left
internal mammary artery graft to left anterior descending artery and Saphenous
vein grafts to posterior descending artery, first and second
Figure-1: 12 lead ECG showing
ST segment elevation of 3mm in aVR,
1.5mm in lead V1 and ST segment depressions of 2-4 mm in
leads I, II, aVL, aVF, V3-6. Bottom strip showing magnified view of
aVR.
Figure-2: Angiographic still
frame showing total occlusion of left anterior descending artery, left
circumflex artery showing 95% proximal stenosis and 80% stenosis of obtuse
marginal
Figure-3: Angiographic still
frame showing proximal total occlusion of right coronary artery with distal vessel
being filled via left system
DISCUSSION
Besides the diagnostic utility of ST segment elevation
in lead aVR during chest pain, this case also highlights some other important
issues in the management of patients with acute coronary syndrome. Although the
patient’s ECG showed signs of severe disease but did not have ST elevations in
two contiguous leads. Hence the patient did not fulfill the criteria for
pharmacological thrombolysis as described in the standard guidelines for
management of acute ST elevation myocardial infarction6. So
according to the guidelines this patient will be treated in the line of non-ST elevation myocardial infarction
(NSTMI). One of the important anti-platelet medications used in this scenario
is clopidogrel. As these patient need urgent coronary angiography and CABG,
withholding clopidogrel will be the best option, as its use is associated with
the complication of excessive bleeding in CABG and this point has been
highlighted by Rajdeep et al in a recent paper.7
Finally these findings have major
implications in countries like Pakistan where there are limited cardiology
centers with coronary artery by-pass grafting facilities and therefore prompt
recognition and proper triage is the only hope for these, seriously ill
patients.
CONCLUSION
The electrocardiographic sign of ST segment elevation
in aVR in 12 lead ECG in patients with acute coronary syndrome can be used as a
marker to prompt early invasive approach and to withhold clopidogrel therapy
particularly in anticipation of CABG surgery.
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_____________________________________________________________________________________________
Address for Correspondence:
Dr. Naveed Akhtar, Dept of Cardiology,
Phone: 051-4446801 (office),
E-mail: samraakhtar@hotmail.com